Endocrine Abstracts

Introduction: The assessment of a new patient in the medical outpatients relies on thorough history taking as well as clinical examination. In particular, biochemical tests are pivotal in the diagnosis of endocrine conditions. Historically, our unit only mostly performed biochemical tests after new patients attended clinic. We proposed that diagnosis and management would be more efficient if this system was reverted, with the aim of minimising the number of clinic appointments...

This presentation will consider the ways that modern genetics and lipidomics are beginning to increase our understanding of specific lipid disorders that bear on human disease, ranging from life-threatening conditions of infancy through severe coronary heart disease of young adulthood, to indolent disorders of middle- and old-age. The case will be made for replacing the traditional, but now 45-year-old, Fredrickson and Lees essentially phenotypic classification of hyperlipidae...

Mutation in the genes encoding subunits of the succinate dehydrogenase enzyme complex, SDHB, SDHC and SDHD are associated with an increased risk of developing adrenal or extra-adrenal phaeochromocytoma and cervical paraganglioma. However, the penetrance in large kindreds has seldom been reported and the optimal screening for asymptomatic carriers has not been determined.The index case had a previous history of carotid body tumour and later died with meta...

Introduction: Increased cardiovascular risk in hypopituitary patients was first documented by Rosen in 1990. Subsequent studies confirmed increased prevalence of cardiovascular and cerebrovascular disease in these patients. The exact mechanism for this is unclear. There is no clear consensus on how best to quantify or predict cardiac risk in hypopituitarism. QRISK2 cardiovascular disease risk algorithm provides estimates of 10-year cardiovascular disease (CVD) risk in patients...

Introduction: The provision of out-of-hours (OOH) care for hospital inpatients is currently a hot political topic with aspirations for ‘seven day working’ and earlier specialist involvement. Care for patients with diabetes or endocrine problems OOH (which accounts for 75% of each week) is variable and often falls as a default to the general medical team. Our centre (over 1000 beds, all major specialities) has, for many years, provided a 24/7 service for GPs and hospi...